Early 21st century.  1978 extrapolation that CO2 could significantly raise global temperatures and dramatically alter the quality of life early in the 21st century.  “Accumulating in the atmosphere at an accelerating rate, carbon dioxide could significantly raise global temperatures by early in the next century and dramatically alter the quality of life. With such a prospect under study, a federal official says: ‘We have about ten years to come up with an answer.’” (No author credited, “Science: Warming Earth? - CO2 may change world climate,” Time Magazine, Monday, Sep. 18, 1978)